I just installed 6.1 perfects in my 03 wagon. Your biggest problem will be the depth of the speakers in the front. I had a 3/4 in spacer, two washers on every screw and I still had to ground down a fastener on the window to make them clear. Everything looks good till you roll down the window then you get a good look at the lack of room in there. I couldn't fit the crossovers for the Perfects anywhere in the door, I had to feed the wire to the map pocket and put the crossovers in there. The tweeter won't give you too much trouble in the stock location, it just doesn't sound too good there. If you can move it, go for it.
In the rears, you might have to cut some door to get the 5.25's to fit. I just put 4" Kappa's running off the HU to fill the space. I spend all the time up front so that's where I sank most of my time and money. Good luck.